Green tea has been in the news quite a bit lately, and for good reason...below are two articles related to the powerful effects green tea has been found to have on cancer.
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Green Tea Reduces Risk of Blood Cancers by 42 Percent
A Japanese green tea study has determined impressive results regarding the reduction of blood and lymph cancers. Tohoku University researchers found a 42 percent reduction for blood cancers and 48 percent reduction for lymph cancers with high green tea consumption.
To arrive at these results, they analyzed the age, gender, lifestyle, and health of 40,000 Japanese over a ten-year period. The statistical observations over time have been bolstered with western clinical application and lab studies that revealed interesting observations.
For example, the Mayo Clinic of Minnesota fed leukemia patients large doses of GTE's (green tea extracts) and discovered immediate benefits in their patients. The doctors consider GTE's a helpful adjunct to orthodox cancer treatments. They declined the notion of using GTE's exclusively or in conjunction with other natural cancer treatments.
Researchers in Spain and England isolated the mechanics of green tea's inhibition of cancer cells. Their research was published in the March 2005 issue of Cancer Research. They found that EGCG, an extremely abundant catechin (active polyphenolic antioxidant metabolites) in green teas, inhibits the enzyme dihydrofolate reductase (DHFR), which are needed by cancer cells to proliferate. Upon closer scrutiny of green tea EGCG, they determined that its molecular structure closely resembles that of the cancer drug methotrexate used in chemotherapy.
source: http://www.telegraph.co.uk/health/healthnews/6325630/Five-cups-of-green-tea-a-day-lowers-cancer-risk.html
Green Tea Extracts May Protect Against Oral Cancer
To arrive at these results, they analyzed the age, gender, lifestyle, and health of 40,000 Japanese over a ten-year period. The statistical observations over time have been bolstered with western clinical application and lab studies that revealed interesting observations.
For example, the Mayo Clinic of Minnesota fed leukemia patients large doses of GTE's (green tea extracts) and discovered immediate benefits in their patients. The doctors consider GTE's a helpful adjunct to orthodox cancer treatments. They declined the notion of using GTE's exclusively or in conjunction with other natural cancer treatments.
Researchers in Spain and England isolated the mechanics of green tea's inhibition of cancer cells. Their research was published in the March 2005 issue of Cancer Research. They found that EGCG, an extremely abundant catechin (active polyphenolic antioxidant metabolites) in green teas, inhibits the enzyme dihydrofolate reductase (DHFR), which are needed by cancer cells to proliferate. Upon closer scrutiny of green tea EGCG, they determined that its molecular structure closely resembles that of the cancer drug methotrexate used in chemotherapy.
source: http://www.telegraph.co.uk/health/healthnews/6325630/Five-cups-of-green-tea-a-day-lowers-cancer-risk.html
Green Tea Extracts May Protect Against Oral Cancer
Extracts from green tea may prevent the formation of mouth cancers in people with risk signs of the disease, according to a new study from Texas.
Over 50 per cent of participants in the University of Texas M. D. Anderson Cancer Center study experienced a clinical response to the green tea extracts, according to findings published in Cancer Prevention Research.
“While still very early, and not definitive proof that green tea is an effective preventive agent, these results certainly encourage more study for patients at highest risk for oral cancer,” lead researcher Vassiliki Papadimitrakopoulou, MD.
“The extract's lack of toxicity is attractive - in prevention trials, it's very important to remember that these are otherwise healthy individuals and we need to ensure that agents studied produce no harm,” he added.
Green tea contains between 30 and 40 per cent of water-extractable polyphenols, while black tea (green tea that has been oxidized by fermentation) contains between 3 and 10 per cent. Oolong tea is semi-fermented tea and is somewhere between green and black tea.
The four primary polyphenols found in fresh tea leaves are epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), and epicatechin (EC).
Phase II Stats
The study, a phase II dose-finding trial, followed 41 people with oral leukoplakia who are at risk for developing oral cancer. The participants were assigned to receive either placebo or green tea extract.
Almost 60 percent of people taking the two highest doses of the green tea extracts had a clinical response. Just over 36 percent of people in the lowest extract dose group had a clinical response, compared to 18 percent in the placebo group, said the researchers.
Commenting on the safety, the researchers noted that side effects such as insomnia and nervousness were mostly only recorded in the high-dose group. None of these produced significant toxicity, they added.
“While these are encouraging findings, much more research must be done before we can conclude that green tea may prevent oral or any other type of cancer. It's also important to remind people that this trial enrolled very few participants who, at the highest dose levels took the equivalent of eight cups of green tea three times a day,” cautioned Papadimitrakopoulo.
“We need to further understand if green tea offers longer-term prevention effects for patients,” he added.
According to the American Cancer Society, more than 35,720 are expected to be diagnosed with oral and/or pharynx cancer and the five year survival rate is less than 50 percent.
Source: Cancer Prevention Research, Volume 2, 931; "Phase II Randomized, Placebo-controlled Trial of Green Tea Extract in Patients with High-risk Oral Premalignant Lesions"; Authors: A.S. Tsao, D. Liu, J. Martin, X. Tang, et al.
Over 50 per cent of participants in the University of Texas M. D. Anderson Cancer Center study experienced a clinical response to the green tea extracts, according to findings published in Cancer Prevention Research.
“While still very early, and not definitive proof that green tea is an effective preventive agent, these results certainly encourage more study for patients at highest risk for oral cancer,” lead researcher Vassiliki Papadimitrakopoulou, MD.
“The extract's lack of toxicity is attractive - in prevention trials, it's very important to remember that these are otherwise healthy individuals and we need to ensure that agents studied produce no harm,” he added.
Green tea contains between 30 and 40 per cent of water-extractable polyphenols, while black tea (green tea that has been oxidized by fermentation) contains between 3 and 10 per cent. Oolong tea is semi-fermented tea and is somewhere between green and black tea.
The four primary polyphenols found in fresh tea leaves are epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), and epicatechin (EC).
Phase II Stats
The study, a phase II dose-finding trial, followed 41 people with oral leukoplakia who are at risk for developing oral cancer. The participants were assigned to receive either placebo or green tea extract.
Almost 60 percent of people taking the two highest doses of the green tea extracts had a clinical response. Just over 36 percent of people in the lowest extract dose group had a clinical response, compared to 18 percent in the placebo group, said the researchers.
Commenting on the safety, the researchers noted that side effects such as insomnia and nervousness were mostly only recorded in the high-dose group. None of these produced significant toxicity, they added.
“While these are encouraging findings, much more research must be done before we can conclude that green tea may prevent oral or any other type of cancer. It's also important to remind people that this trial enrolled very few participants who, at the highest dose levels took the equivalent of eight cups of green tea three times a day,” cautioned Papadimitrakopoulo.
“We need to further understand if green tea offers longer-term prevention effects for patients,” he added.
According to the American Cancer Society, more than 35,720 are expected to be diagnosed with oral and/or pharynx cancer and the five year survival rate is less than 50 percent.
Source: Cancer Prevention Research, Volume 2, 931; "Phase II Randomized, Placebo-controlled Trial of Green Tea Extract in Patients with High-risk Oral Premalignant Lesions"; Authors: A.S. Tsao, D. Liu, J. Martin, X. Tang, et al.
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